Journal article
Long-term weight loss after colorectal cancer diagnosis is associated with lower survival: The Colon Cancer Family Registry
JM Kocarnik, X Hua, S Hardikar, J Robinson, NM Lindor, AK Win, JL Hopper, JC Figueiredo, JD Potter, PT Campbell, S Gallinger, M Cotterchio, SV Adams, SA Cohen, AI Phipps, PA Newcomb
Cancer | WILEY | Published : 2017
DOI: 10.1002/cncr.30932
Abstract
BACKGROUND: Body weight is associated with colorectal cancer (CRC) risk and survival, but to the authors' knowledge, the impact of long-term postdiagnostic weight change is unclear. Herein, the authors investigated whether weight change over the 5 years after a diagnosis of CRC is associated with survival. METHODS: CRC cases diagnosed from 1997 to 2008 were identified through 4 population-based cancer registry sites. Participants enrolled within 2 years of diagnosis and reported their height and weight 2 years prior. Follow-up questionnaires were administered approximately 5 years after diagnosis. Associations between change in weight (in kg) or body mass index (BMI) with overall and CRC-spe..
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Awarded by National Institutes of Health
Funding Acknowledgements
Supported by grants from the National Cancer Institute (K05 CA152715, K07 CA172298, and UM1 CA167551) and the National Center for Advancing Translational Sciences (KL2 TR000421) at the National Institutes of Health, and through cooperative agreements with the following centers: the Australasian Colorectal Cancer Family Registry (grants U01 CA074778 and U01/U24 CA097735), the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (grant U01/U24 CA074800), the Ontario Familial Colorectal Cancer Registry (grant U01/U24 CA074783), and the Seattle Colorectal Cancer Family Registry (grant U01/U24 CA074794). Seattle Colorectal Cancer Family Registry research also was supported by the Cancer Surveillance System of the Fred Hutchinson Cancer Research Center, which was funded by controls N01-CN-67009 (1996-2003) and N01-PC-35142 (2003-2010) and contract HHSN2612013000121 (2010-2017) from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute with additional support from the Fred Hutchinson Cancer Research Center.